ICG2013
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Diether Lambrechts
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University of Leuven
Belgium
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Biography:
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Research Expertise:
Before 2008 (PhD student, Post E doc): Functional genomics in mice!and fish to decipher the role of the VEGF and hypoxia in neurodegeneration. Expertise: Molecular biology (RNA/DNA/protein isolation, Western blotting, ELISA, etc), mouse genetics (gene-targeting and generation of transgenic mice), Experimental surgery for neurodegenerative disease models, histology, recombinant proteins (production/purification in E coli and P pastoris), cell biology, gene therapy (adenoviral and adeno-associated vectors), etc. After 2008 (independent researcher): Unraveling the genetic and! epigenetic mechanisms during carcinogenesis with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies (with a focus on anti-VEGF therapy and hypoxia). Expertise: Biomarker research within phase 2/3 clinical trials, hot-spot mutation profiling of oncogenes(Sequenom), targeted resequencing, whole-genome and exome-sequecing of tumors (mouse and human tissue, fresh-frozen and FFPE), transcriptomics (RNA-seq), Epigenome profiling (mDIP-seq, hmDIP-seq, WGBS8 seq), development of data-analysis pipelines, functional validation of genetic markers using genomics (transfection, siRNA technology, genome editing, etc), tumor models(xenografts and xenopatients), etc
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